Modafinil is known being a weak inhibitor of dopamine reuptake, which may be its Major clinically critical property. It has small to no in vivo affinity for that serotonin (5HT) or norepinephrine (NE) transporters. Even so, elevated concentrations of NE and 5HT from the prefrontal cortex and hypothalamus are actually observed subsequent modafinil administration, perhaps as an indirect effect of elevated extracellular dopamine.

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Other Healthcare Difficulties The existence of other healthcare problems may well influence the use of this drugs. Be sure to inform your health practitioner For those who have any other clinical issues, Specifically:

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You shouldn't use Provigil Should you have at any time experienced an allergic reaction or pores and skin rash whilst taking modafinil or armodafinil (Nuvigil).

Small (one)modafinil will enhance the stage or impact of pantoprazole by impacting hepatic enzyme CYP2C19 metabolism. Small/Significance Not known. Internet effect on pantoprazole steps unfamiliar resulting from opposing results of CYP450 enzymes; keep track of

Modafinil is actually a stimulant medication that is usually Protected, properly-tolerated, and carries a very low likely for abuse and dependence. It really is utilized to treat excessive daytime sleepiness connected with narcolepsy, slumber work shift disorder, and obstructive sleep apnea. It is usually used in conjunction with other health care and Life style treatment options for these conditions. Most people can safely receive modafinil, Even though it ought to be made use of cautiously in people with structural cardiac sickness, critical hepatic impairment, or simply a historical past of psychosis/mania.

Stay clear of or substitute A further drug for these medicines when achievable. Appraise for lack of therapeutic impact if medication have to be coadministered. Modify dose Based on prescribing details if required.

cenobamate will boost the stage or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Closely. Take into consideration a dose reduction of CYP2C19 substrates, as clinically proper, when made use of concomitantly with cenobamate.

An overdose of modafinil can lead to An array of indications and complications. Psychiatric indicators might include psychosis, mania, hallucinations, and suicidal ideation, that may come about even in men and women with no history of psychological illness and should persist immediately after discontinuation with the drug.

Other drugs may perhaps connect with modafinil, which includes prescription and in excess of-the-counter medicines, vitamins, and herbal products. Explain to Each individual within your health and fitness treatment providers about all medicines you employ now and any drugs you start or halt using.

Provigil will likely not overcome obstructive slumber apnea or address its fundamental causes. here Follow your physician's Directions about all your other remedies for this condition.

Stay away from or substitute One more drug for these remedies when probable. Evaluate for lack of therapeutic effect if medication should be coadministered.

Furthermore, various intentional acute overdoses happened; the two major getting 4500 mg and 4000 mg taken by two topics taking part in foreign depression reports. None of such study subjects seasoned any unanticipated or life-threatening results. Adverse reactions that were described at these doses bundled excitation or agitation, sleeplessness, and slight or average elevations in hemodynamic parameters.